Spencer was one of the founders and an executive member of the Social Problems Club. She was influential in bringing Black speakers to Mount Holyoke including Mordecai Johnson, former president of Howard University, Eugene Gordon, officer in the League of Struggle for Negro Rights, and Walter White, former executive secretary of the NAACP. Spencer was also heavily involved in campus clubs including the YWCA, Cosmopolitan Club, Peace Club, and Model League of Nations.
Spencer’s honors project was on sharecropping and she spent part of her spring vacation in Orangeburg county in South Carolina, the wealthiest cotton county in that state. She graduated cum laude. After graduation she attended law school at Wayne State University, later opening a law office in Detroit, MI.